Abstract:

Objective To investigate the correlations of microinvasion (MI) with other clinicopathologic parameters in the patients with breast ductal carcinoma in situ (DCIS).Methods The clinical data of totally 131 patients with DCIS treated in our hospital from October 2006 to October 2012 were retrospectively analyzed.Spearman correlation analysis was applied to detect the correlation between DCIS-MI, lymph node metastasis and pathologic grades. Fisher’s exact test was used to detect the correlation between DCIS-MI and lymph node metastasis, and analyze the influence of operation methods, pathologic grades, DCIS-MI and axillary lymph node dissection on recurrence.Results (1) In 131 cases of DCIS, there were 60 cases in low grade of DCIS(45.8%),60 in intermediate grade (45.8%) and 11 in high grade (8.4%). The microinvasion was found in 12,31 and 8 cases in each pathologic grade respectively, which implied that DCIS-MI was correlated with pathologic grades (r=0.375, P=0.000). (2) Seventy-six patients received sentinel lymph node biopsy and lymph node metastasis was found in 3 cases;56 patients received axillary lymph node dissection and lymph node metastasis was found in 5 cases. The incidence of axillary lymph node metastasis was related with DCIS-MI(P=0.015), but not correlated with pathologic grades (r=0.154, P=0.107). (3) During the follow-up of 3-72 months,1 case died of apoplexy,3 cases experienced a local recurrence and none died of breast cancer.The recurrence of DCIS was not related with operation methods, pathologic grades, DCIS-MI and axillary lymph node dissection (P=0.359,1.000,1.000,0.260).Conclusion The patients with higher pathologic grades of DCIS have a higher risk of DCIS-MI; the patients with DCIS-MI have a higher risk of axillary lymph node metastasis.

Key words: Breast neoplasms, Carcinoma in situ, Pathology, Lymphocytes, tumor-infiltrating, Prognosis